Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish.
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ABSTRACT:
SUBMITTER: Yuan Q
PROVIDER: S-EPMC3535582 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish.
Yuan Qiuping Q Chiquet Brett T BT Devault Laura L Warman Matthew L ML Nakamura Yukio Y Swindell Eric C EC Hecht Jacqueline T JT
Genesis (New York, N.Y. : 2000) 20120821 12
Nonsyndromic cleft lip and palate (NSCLP), a common birth defect, affects 4,000 newborns in the US each year. Previously, we described an association between CRISPLD2 and NSCLP and showed Crispld2 expression in the murine palate. These results suggested that a perturbation in CRISPLD2 activity affects craniofacial development. Here, we describe crispld2 expression and the phenotypic consequence of its loss of function in zebrafish. crispld2 was expressed at all stages of zebrafish morphogenesis ...[more]
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