Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.
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ABSTRACT:
SUBMITTER: Cao CY
PROVIDER: S-EPMC3535584 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.
Cao Chun-Yan CY Shen Ying-Ying YY Wang Jian-Dong JD Li Li L Liang Gao-Lin GL
Scientific reports 20130103
Herein we developed a new "smart" Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 folds of those of 1 and magnevist at 1.5 T, and 1.4 folds of that of 1 at 3 T. Intracellular condensation of 1 in furin-overexpressed MDA-MB-468 cells was proven with direct two-photon laser microscopy ...[more]
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