Ontology highlight
ABSTRACT:
SUBMITTER: Kwon M
PROVIDER: S-EPMC3535663 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kwon Michelle M Pavlov Tengis S TS Nozu Kandai K Rasmussen Shauna A SA Ilatovskaya Daria V DV Lerch-Gaggl Alexandra A North Lauren M LM Kim Hyunho H Qian Feng F Sweeney William E WE Avner Ellis D ED Blumer Joe B JB Staruschenko Alexander A Park Frank F
Proceedings of the National Academy of Sciences of the United States of America 20121210 52
Polycystic kidney diseases are the most common genetic diseases that affect the kidney. There remains a paucity of information regarding mechanisms by which G proteins are regulated in the context of polycystic kidney disease to promote abnormal epithelial cell expansion and cystogenesis. In this study, we describe a functional role for the accessory protein, G-protein signaling modulator 1 (GPSM1), also known as activator of G-protein signaling 3, to act as a modulator of cyst progression in an ...[more]