Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
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ABSTRACT:
SUBMITTER: Kakiuchi S
PROVIDER: S-EPMC3536242 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
Kakiuchi Satsuki S Nonoyama Shigeaki S Wakamatsu Hajime H Kogawa Kazuhiro K Wang Lixin L Kinoshita-Yamaguchi Hitomi H Takayama-Ito Mutsuyo M Lim Chang-Kweng CK Inoue Naoki N Mizuguchi Masashi M Igarashi Takashi T Saijo Masayuki M
Journal of clinical microbiology 20121024 1
A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance. ...[more]
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