Ontology highlight
ABSTRACT:
SUBMITTER: Yang DH
PROVIDER: S-EPMC3536287 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Yang Dong-Hoon DH Maeng Shinae S Strain Anna K AK Floyd Anna A Nielsen Kirsten K Heitman Joseph J Bahn Yong-Sun YS
Eukaryotic cell 20121005 12
Msi1-like (MSIL) proteins contain WD40 motifs and have a pleiotropic cellular function as negative regulators of the Ras/cyclic AMP (cAMP) pathway and components of chromatin assembly factor 1 (CAF-1), yet they have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, in Cryptococcus neoformans, which causes life-threatening meningoencephalitis in humans. Notably, Msl1 plays pleiotropic roles in C. neoformans in both cAMP-dependent and -independent ma ...[more]