Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC3536363 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Xu Lai L Elkahloun Abdel G AG Candotti Fabio F Grajkowski Andrzej A Beaucage Serge L SL Petricoin Emanuel F EF Calvert Valerie V Juhl Hartmut H Mills Frederick F Mason Karen K Shastri Neal N Chik Josh J Xu Cynthia C Rosenberg Amy S AS
Journal of virology 20121024 1
The human genome contains approximately 50 copies of the replication-defective human endogenous retrovirus 9 (ERV-9) and thousands of copies of its solitary long term repeat (sLTR) element. While some sLTRs are located upstream of critical genes and have enhancer activity, other sLTRs are located within introns and may be transcribed as RNAs. We found that intronic RNAs arising from U3 sLTRs of ERV-9 were expressed as both sense (S) and antisense (AS) transcripts in all human cells tested but th ...[more]