Ontology highlight
ABSTRACT:
SUBMITTER: Zinder D
PROVIDER: S-EPMC3536651 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Zinder Daniel D Bedford Trevor T Gupta Sunetra S Pascual Mercedes M
PLoS pathogens 20130103 1
Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2-8 years) lineage. Classically, this has been modeled by limiting the generation of new successful antigenic variants, such that only a small subset of progeny acquire the necessary mutations to evade host immunity. A ...[more]