Ontology highlight
ABSTRACT:
SUBMITTER: Mata IF
PROVIDER: S-EPMC3536918 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Movement disorders : official journal of the Movement Disorder Society 20121031 14
<h4>Background</h4>Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear.<h4>Methods</h4>We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P < .05) were then genotyped in an independent sample of 3617 cases and 2512 controls from the United States and Spain (tier 2) ...[more]