Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC3537022 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Yang Shengyu S Huang Fang-Ke FK Huang Jianyun J Chen Shuai S Jakoncic Jean J Leo-Macias Alejandra A Diaz-Avalos Ruben R Chen Lin L Zhang J Jillian JJ Huang Xin-Yun XY
The Journal of biological chemistry 20121126 1
Filopodia are cell surface protrusions that are essential for cell migration. This finger-like structure is supported by rigid tightly bundled actin filaments. The protein responsible for actin bundling in filopodia is fascin. However, the mechanism by which fascin functions in filopodial formation is not clear. Here we provide biochemical, cryo-electron tomographic, and x-ray crystal structural data demonstrating the unique structural characteristics of fascin. Systematic mutagenesis studies on ...[more]