IL-37 is a fundamental inhibitor of innate immunity.
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ABSTRACT:
SUBMITTER: Nold MF
PROVIDER: S-EPMC3537119 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
IL-37 is a fundamental inhibitor of innate immunity.
Nold Marcel F MF Nold Marcel F MF Nold-Petry Claudia A CA Zepp Jarod A JA Palmer Brent E BE Bufler Philip P Dinarello Charles A CA
Nature immunology 20101010 11
The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. Anti-inflammatory cytokines were unaffected. Mice with transgenic expression of IL-37 were protected from lipopolysaccharide-induced shock, and showed markedly improved lung ...[more]
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