Ontology highlight
ABSTRACT:
SUBMITTER: Hodak H
PROVIDER: S-EPMC3537140 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Hodak Hélène H Galán Jorge E JE
EMBO reports 20121123 1
Unlike other Salmonella, which can infect a broad range of hosts causing self-limiting infection, Salmonella Typhi is an exclusively human pathogen that causes typhoid fever, a life-threatening systemic disease. Typhoid toxin is a unique virulence factor of Salmonella Typhi, which is expressed when the bacteria are within mammalian cells. Here, we report that an N-acetyl-β-D-muramidase similar to phage endolysins encoded within the same pathogenicity islet as the toxin is required for typhoid to ...[more]