Inhibition of WISE preserves renal allograft function.
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ABSTRACT:
SUBMITTER: Qian X
PROVIDER: S-EPMC3537210 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Inhibition of WISE preserves renal allograft function.
Qian Xueming X Yuan Xiaodong X Vonderfecht Steven S Ge Xupeng X Lee Jae J Jurisch Anke A Zhang Li L You Andrew A Fitzpatrick Vincent D VD Williams Alexia A Valente Eliane G EG Pretorius Jim J Stevens Jennitte L JL Tipton Barbara B Winters Aaron G AG Graham Kevin K Harriss Lindsey L Baker Daniel M DM Damore Michael M Salimi-Moosavi Hossein H Gao Yongming Y Elkhal Abdallah A Paszty Chris C Simonet W Scott WS Richards William G WG Tullius Stefan G SG
Journal of the American Society of Nephrology : JASN 20121126 1
Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed in renal transplants developing interstitial fibrosis and tubular atrophy; however, whether WISE contributes to chronic changes is not well understood. Here, we found moderate to high expression of WISE mRNA in a rat model of renal transplantation and in kidneys from normal rats. Treatment with a neutralizing antibody against WISE improved ...[more]
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