Ontology highlight
ABSTRACT:
SUBMITTER: Dhaun N
PROVIDER: S-EPMC3537212 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Dhaun Neeraj N Melville Vanessa V Blackwell Scott S Talwar Dinesh K DK Johnston Neil R NR Goddard Jane J Webb David J DJ
Journal of the American Society of Nephrology : JASN 20121214 1
Arterial stiffness and impaired nitric oxide (NO) bioavailability contribute to the high risk for cardiovascular disease in CKD. Both asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO production, and endothelin-1 (ET-1) oppose the actions of NO, suggesting that ET-1 receptor antagonists may have a role in cardiovascular protection in CKD. We conducted a randomized, double-blind, three-way crossover study in 27 patients with proteinuric CKD to compare the effects of the ET(A) rece ...[more]