Ontology highlight
ABSTRACT:
SUBMITTER: Ribaudo HJ
PROVIDER: S-EPMC3537445 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20121112 3
The UGT1A1*28 variant has been associated with hyperbilirubinemia and atazanavir discontinuation. Protocol A5202 randomly assigned human immunodeficiency virus type 1 (HIV-1)-infected patients to receive atazanavir/ritonavir (atazanavir/r) or efavirenz, with tenofovir/emtricitabine or abacavir/lamivudine. A total of 646 atazanavir/r recipients were evaluable for UGT1A1. Homozygosity for *28/*28 was present in 8% of whites, 24% of blacks, and 18% of Hispanics and was associated with increased bil ...[more]