Promoting nerve cell functions on hydrogels grafted with poly(L-lysine).
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ABSTRACT:
SUBMITTER: Cai L
PROVIDER: S-EPMC3538025 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Promoting nerve cell functions on hydrogels grafted with poly(L-lysine).
Cai Lei L Lu Jie J Sheen Volney V Wang Shanfeng S
Biomacromolecules 20120201 2
We present a novel photopolymerizable poly(L-lysine) (PLL) and use it to modify polyethylene glycol diacrylate (PEGDA) hydrogels for creating a better, permissive nerve cell niche. Compared with their neutral counterparts, these PLL-grafted hydrogels greatly enhance pheochromocytoma (PC12) cell survival in encapsulation, proliferation, and neurite growth and also promote neural progenitor cell proliferation and differentiation capacity, represented by percentages of both differentiated neurons a ...[more]
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