Unknown

Dataset Information

0

Design, synthesis, and validation of a branched flexible linker for bioactive peptides.

ABSTRACT: A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

SUBMITTER: Bowen ME 

PROVIDER: S-EPMC3538035 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Design, synthesis, and validation of a branched flexible linker for bioactive peptides.

Bowen Martina E ME   Monguchi Yasunari Y   Sankaranarayanan Rajesh R   Vagner Josef J   Begay Lucinda J LJ   Xu Liping L   Jagadish Bhumasamudram B   Hruby Victor J VJ   Gillies Robert J RJ   Mash Eugene A EA  

The Journal of organic chemistry 20070206 5

A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone. ...[more]

Similar Datasets

Unknown Squalene-derived flexible linkers for bioactive peptides.
| S-EPMC2033335 | biostudies-literature
Unknown Design of antiviral stapled peptides containing a biphenyl cross-linker.
| S-EPMC4005879 | biostudies-literature
Unknown Design, Synthesis, and Cytotoxicity Assessment of [64Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker.
| S-EPMC8469169 | biostudies-literature
Unknown Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.
| S-EPMC1174920 | biostudies-literature
Unknown Design of bioactive peptides from naturally occurring μ-conotoxin structures.
| S-EPMC3438967 | biostudies-literature
Unknown Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition.
| S-EPMC4092256 | biostudies-literature
Unknown Design, Synthesis and Evaluation of Branched RRWQWR-Based Peptides as Antibacterial Agents Against Clinically Relevant Gram-Positive and Gram-Negative Pathogens.
| S-EPMC5840262 | biostudies-literature
Unknown De novo design of conformationally flexible transmembrane peptides driving membrane fusion.
| S-EPMC522031 | biostudies-other
Unknown Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates.
| S-EPMC4359053 | biostudies-literature
Unknown TmPrime: fast, flexible oligonucleotide design software for gene synthesis.
| S-EPMC2703938 | biostudies-literature