Ontology highlight
ABSTRACT:
SUBMITTER: Su L
PROVIDER: S-EPMC3538133 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Su Linlin L Mruk Dolores D DD Lie Pearl P Y PP Silvestrini Bruno B Cheng C Yan CY
Nature communications 20120101
Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of the blood-testis barrier, which facilitates the transit of preleptotene spermatocytes. Here we determine the biologically active domain in laminin-γ3 domain IV, which we designate F5 ...[more]