Ontology highlight
ABSTRACT:
SUBMITTER: Shao K
PROVIDER: S-EPMC3538313 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Shao Kaifeng K Koch Carmen C Gupta Manoj K MK Lin Qiong Q Lenz Michael M Laufs Stephanie S Denecke Bernd B Schmidt Manfred M Linke Matthias M Hennies Hans C HC Hescheler Jürgen J Zenke Martin M Zechner Ulrich U Šarić Tomo T Wagner Wolfgang W
Molecular therapy : the journal of the American Society of Gene Therapy 20121002 1
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about interindividual epigenetic variation. We have reprogrammed mesenchymal stromal cells from human bone marrow (iP-MSC) and compared their DNA methylation profiles with initial MSC and embryonic stem cells (ESCs) using high-density DNA methylation arrays covering more than 450,000 CpG sites. Overall, ...[more]