Symptomatic atherosclerosis is associated with an altered gut metagenome.
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ABSTRACT:
SUBMITTER: Karlsson FH
PROVIDER: S-EPMC3538954 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Symptomatic atherosclerosis is associated with an altered gut metagenome.
Karlsson Fredrik H FH Fåk Frida F Nookaew Intawat I Tremaroli Valentina V Fagerberg Björn B Petranovic Dina D Bäckhed Fredrik F Nielsen Jens J
Nature communications 20120101
Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclero ...[more]
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