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The palladium-catalyzed anti-Markovnikov hydroalkylation of allylic alcohol derivatives.
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ABSTRACT:
SUBMITTER: DeLuca RJ
PROVIDER: S-EPMC3539300 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
The palladium-catalyzed anti-Markovnikov hydroalkylation of allylic alcohol derivatives.
Organic letters 20121219 1
A palladium-catalyzed hydroalkylation reaction of protected allylic alcohols using alkylzinc bromide reagents is reported. This account includes numerous allylic, homoallylic, and bishomoallylic alcohol derivatives, all with a uniform selectivity of >20:1 for the anti-Markovnikov product. The reaction features the ability to deliver enantiomerically enriched alcohols in unfunctionalized regions, which results from the catalyst avoiding β-hydride elimination at the allylic position. ...[more]