Calibrating BOLD fMRI activations with neurovascular and anatomical constraints.

ABSTRACT: Functional magnetic resonance imaging signals, in addition to reflecting neuronal response, also contain physiological variances. These factors may introduce variability into blood oxygen level-dependent (BOLD) activation results, particularly in different population groups. In this study, we hypothesized that the amplitude as well as the spatial extent of BOLD activation could be improved after minimizing the variance caused by the neurovascular and anatomical factors. Subjects were scanned while they performed finger tapping and digit-symbol substitution tasks (DSSTs). Partial volume and neurovascular effects were estimated on a voxelwise basis using subjects' own gray matter volume (GMV), breath holding (BH), and amplitude of low-frequency fluctuation (ALFF). The results showed that all

SUBMITTER: Di X 

PROVIDER: S-EPMC3539449 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature