An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes.

ABSTRACT:

Unlabelled

Background

Microarray technology may offer a new opportunity to gain insight into disease-specific global protein expression profiles. The present study was performed to apply a serum antibody microarray to screen for differentially regulated cytokines in Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS).

Results

Serum samples were obtained from patients with clinical diagnoses of PD (n = 117), MSA (n = 31) and PSP/CBS (n = 38) and 99 controls. Cytokine profiles of sera from patients and controls were analyzed with a semiquantitative human antibody array for 174 cytokines and the expression of 12 cytokines was found to be significantly altered. In a next step, results from the micr

SUBMITTER: Mahlknecht P 

PROVIDER: S-EPMC3539904 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature