Dataset Information

Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study.

ABSTRACT:

Objectives

To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event.

Methods

We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months.

Results

The time to first relapse decreased and the number of relapses increased with anti-CMV IgG positivity. Smoking was associated with increased number and volume of contrast-enhancing lesions (CEL) during the 2-year period. The cumulative number of CEL and T2 lesions during the 2-year period was greater for individuals in the highest quartile of anti-EBV VCA IgG antibodies. The percent loss of brain volume was increased for those in the highest quartile of with anti-EBV VCA IgG antibodies.

Conclusions

Relapses in CIS patients were associated with CMV positivity whereas anti-EBV VCA positivity was associated with progression on MRI measures, including accumulation of CEL and T2 lesions and development of brain atrophy.

SUBMITTER: Horakova D

PROVIDER: S-EPMC3540021 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study.

Horakova Dana D Zivadinov Robert R Weinstock-Guttman Bianca B Havrdova Eva E Qu Jun J Tamaño-Blanco Miriam M Badgett Darlene D Tyblova Michaela M Bergsland Niels N Hussein Sara S Willis Laura L Krasensky Jan J Vaneckova Manuela M Seidl Zdenek Z Lelkova Petra P Dwyer Michael G MG Zhang Ming M Yu Haoying H Duan Xiaotao X Kalincik Tomas T Ramanathan Murali M

PloS one 20130108 1

<h4>Objectives</h4>To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event.<h4>Methods</h4>We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EB ...[more]

PMID: 23320113

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Dataset Information

Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study.

Objectives

Methods

Results

Conclusions

Publications

Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study.

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