Ontology highlight
ABSTRACT:
SUBMITTER: Severin PM
PROVIDER: S-EPMC3540242 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Severin Philip M D PM Zou Xueqing X Schulten Klaus K Gaub Hermann E HE
Biophysical journal 20130108 1
Cytosine hydroxymethylation is an epigenetic control factor in higher organisms. New discoveries of the biological roles of hydroxymethylation serve to raise questions about how this epigenetic modification exerts its functions and how organisms discriminate cytosine hydroxymethylation from methylation. Here, we report investigations that reveal an effect of cytosine hydroxymethylation on mechanical properties of DNA under load. The findings are based on molecular force assay measurements and st ...[more]