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Early detection biomarkers for ovarian cancer.


ABSTRACT: Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.

SUBMITTER: Sarojini S 

PROVIDER: S-EPMC3540796 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Early detection biomarkers for ovarian cancer.

Sarojini Sreeja S   Tamir Ayala A   Lim Heejin H   Li Shihong S   Zhang Shifang S   Goy Andre A   Pecora Andrew A   Suh K Stephen KS  

Journal of oncology 20121223


Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultraso  ...[more]

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