Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell PS
PROVIDER: S-EPMC3540999 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Mitchell Patrick S PS Patzina Corinna C Emerman Michael M Haller Otto O Malik Harmit S HS Kochs Georg G
Cell host & microbe 20121001 4
MxA is an interferon-induced dynamin-like GTPase with wide-ranging antiviral activity, which hinges upon detection of unique viral structures that differ across virus families. Despite elucidation of its structure, the basis of MxA antiviral specificity remains enigmatic. We used an evolution-guided approach to identify the loop L4 of MxA as a hotspot for recurrent positive selection in primates. Further, we show that single amino acid changes in L4 are necessary and sufficient to explain dramat ...[more]