An RS motif within the Epstein-Barr virus BLRF2 tegument protein is phosphorylated by SRPK2 and is important for viral replication.
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ABSTRACT:
SUBMITTER: Duarte M
PROVIDER: S-EPMC3541133 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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An RS motif within the Epstein-Barr virus BLRF2 tegument protein is phosphorylated by SRPK2 and is important for viral replication.
Duarte Melissa M Wang Lili L Calderwood Michael A MA Adelmant Guillaume G Ohashi Makoto M Roecklein-Canfield Jennifer J Marto Jarrod A JA Hill David E DE Deng Hongyu H Johannsen Eric E
PloS one 20130109 1
Epstein-Barr virus (EBV) is a gammaherpesvirus that causes infectious mononucleosis, B cell lymphomas, and nasopharyngeal carcinoma. Many of the genes required for EBV virion morphogenesis are found in all herpesviruses, but some are specific to gammaherpesviruses. One of these gamma-specific genes, BLRF2, encodes a tegument protein that has been shown to be essential for replication in other gammaherpesviruses. In this study, we identify BLRF2 interacting proteins using binary and co-complex pr ...[more]
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