Genome wide comparative comprehensive analysis of Plasmodium falciparum MCM family with human host.
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ABSTRACT:
SUBMITTER: Ansari A
PROVIDER: S-EPMC3541329 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Genome wide comparative comprehensive analysis of Plasmodium falciparum MCM family with human host.
Ansari Abulaish A Tuteja Renu R
Communicative & integrative biology 20121101 6
Mini chromosome maintenance (MCM) proteins 2-7, a subgroup of the large AAA ATPase family are critically required for eukaryotic DNA replication. These proteins are most likely responsible for unwinding DNA at the replication forks. Besides this function, some MCMs are also involved in other chromosome transactions such as transcription, chromatin remodeling and genome stability. All the MCMs contain a conserved region of ~200 amino acids responsible for nucleotide binding. The importance of MCM ...[more]
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