Ontology highlight
ABSTRACT:
SUBMITTER: Torricelli C
PROVIDER: S-EPMC3541534 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Torricelli Claudia C Salvadori Sara S Valacchi Giuseppe G Souček Karel K Slabáková Eva E Muscettola Michela M Volpi Nila N Maioli Emanuela E
Evidence-based complementary and alternative medicine : eCAM 20121220
Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic compound with antiproliferative effects in several cell types, can induce cell death in MCF-7 breast cancer cells. The MCF-7 cell line is a good model of chemo/radio resistance, being both apoptosis and autophagy resistant, due to deletion of caspase 3 ...[more]