Ontology highlight
ABSTRACT:
SUBMITTER: Negoro H
PROVIDER: S-EPMC3541943 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Negoro Hiromitsu H Kanematsu Akihiro A Doi Masao M Suadicani Sylvia O SO Matsuo Masahiro M Imamura Masaaki M Okinami Takeshi T Nishikawa Nobuyuki N Oura Tomonori T Matsui Shigeyuki S Seo Kazuyuki K Tainaka Motomi M Urabe Shoichi S Kiyokage Emi E Todo Takeshi T Okamura Hitoshi H Tabata Yasuhiko Y Ogawa Osamu O
Nature communications 20120501
Nocturnal enuresis in children and nocturia in the elderly are two highly prevalent clinical conditions characterized by a mismatch between urine production rate in the kidneys and storage in the urinary bladder during the sleep phase. Here we demonstrate, using a novel method for automated recording of mouse micturition, that connexin43, a bladder gap junction protein, is a negative regulator of functional bladder capacity. Bladder connexin43 levels and functional capacity show circadian oscill ...[more]