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Functional promoter -308G>A variant in tumor necrosis factor ? gene is associated with risk and progression of gastric cancer in a Chinese population.

ABSTRACT:

Background

Tumor necrosis factor-? (TNF-?) plays a crucial role in the development and progression of gastric cancer. A functional polymorphism, -308 G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-? and influence cancer risk. In the present study, we sought to investigate whether this polymorphism has effects on the risk and progression of gastric cancer in a Chinese population.

Methods

We genotyped the TNFA -308 G>A polymorphism using the TaqMan method in a two-stage case-control study comprising a total of 1686 gastric cancer patients and 1895 cancer-free subjects. The logistic regression was used to assess the genetic associations with occurrence and progression of gastric cancer.

Results

We found a significant association between the variant genotypes and increased risk of gastric cancer [P?=?0.034, odds ratio (OR)?=?1.39, 95% confidence interval (CI)?=?1.01-1.67, GA/AA vs. GG]. Similar results were observed in the follow-up replication study. When combined the data from the two studies, we found a more significant association (P?=?0.001, OR?=?1.34, 95%CI?=?1.13-1.59), especially for older subjects (>65 years). Furthermore, the patients carrying the variant genotypes had a significantly greater prevalence of T4 stage of disease (P?=?0.001, OR?=?2.19, 95%CI?=?1.39-3.47) and distant metastasis (P?=?0.013, OR?=?1.61, 95%CI?=?1.10-2.35).

Conclusions

Our results suggest that the functional promoter -308 G>A polymorphism in TNFA influence the susceptibility and progression of gastric cancer in the Chinese population.

SUBMITTER: Hong Y

PROVIDER: S-EPMC3542372 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population.

Hong Yan Y Ge Zhijun Z Jing Changrui C Shi Jun J Dong Xiao X Zhou Fengying F Wang Meilin M Zhang Zhengdong Z Gong Weida W

PloS one 20130110 1

<h4>Background</h4>Tumor necrosis factor-α (TNF-α) plays a crucial role in the development and progression of gastric cancer. A functional polymorphism, -308 G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk. In the present study, we sought to investigate whether this polymorphism has effects on the risk and progression of gastric cancer in a Chinese population.<h4>Methods</h4>We genotyped the TNFA -308 G ...[more]

PMID: 23326309

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