Ontology highlight
ABSTRACT:
SUBMITTER: Gangloff M
PROVIDER: S-EPMC3542428 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20121213 1
Drosophila melanogaster Toll is the founding member of an important family of pathogen-recognition receptors in humans, the Toll-like receptor (TLR) family. In contrast, the prototypical receptor is a cytokine-like receptor for Spätzle (Spz) protein and plays a dual role in both development and immunity. Here, we present the crystal structure of the N-terminal domain of the receptor that encompasses the first 201 amino acids at 2.4 Å resolution. To our knowledge, the cysteine-rich cap adopts a n ...[more]