Ontology highlight
ABSTRACT:
SUBMITTER: Rautureau GJ
PROVIDER: S-EPMC3542614 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Rautureau G J P GJ Yabal M M Yang H H Huang D C S DC Kvansakul M M Hinds M G MG
Cell death & disease 20121213
B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from other Bcl-2 family members through an insertion of an unstructured loop between helices α5 and α6. Probing Bcl-B interactions with Bcl-2 homology (BH)3 motifs using a combination of biophysical- and c ...[more]