Ontology highlight
ABSTRACT:
SUBMITTER: Shimamura S
PROVIDER: S-EPMC3543001 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Shimamura Shintaro S Sasaki Kazuki K Tanaka Masamitsu M
The Journal of biological chemistry 20121116 2
In our attempt to screen for substrates of Src family kinases in glioblastoma, Src kinase-associated phosphoprotein 2 (SKAP2) was identified. Although SKAP2 has been suggested to be associated with integrin-mediated adhesion of hematopoietic cells, little is known about its molecular function and the effects in other types of cells and tumors. Here, we demonstrate that SKAP2 physically associates with actin assembly factors WAVE2 and cortactin and inhibits their interaction. Cortactin is require ...[more]