Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population.

ABSTRACT:

Background

Rho-kinase (ROCK) has been shown to play an important role in cardiovascular disease such as coronary artery disease (CAD) and hypertension. Recently, common variants of ROCK2 have been reported to influence blood pressure, but the relationship between common ROCK2 variants and cardiovascular disease has not been extensively studied in the Chinese population.

Methods

To derive a more precise estimation of their relationship, we screened for the common variants by direct sequencing of all exons of ROCK2, and then we performed genetic association analyses in a CAD case-control study, including a total of 1344 cases and 1267 ethnically and geographically matched controls.

Results

Unconditional logistic regression showed that no significant association between

SUBMITTER: Liu L 

PROVIDER: S-EPMC3543257 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature