Ontology highlight
ABSTRACT:
SUBMITTER: Gaudio E
PROVIDER: S-EPMC3544116 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Gaudio Eugenio E Paduano Francesco F Ngankeu Apollinaire A Lovat Francesca F Fabbri Muller M Sun Hui-Lung HL Gasparini Pierluigi P Efanov Alexey A Peng Yong Y Zanesi Nicola N Shuaib Mohammed A MA Rassenti Laura Z LZ Kipps Thomas J TJ Li Chenglong C Aqeilan Rami I RI Lesinski Gregory B GB Trapasso Francesco F Croce Carlo M CM
Blood 20121115 2
T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas. To date, only a limited number of Tcl1-interacting proteins that regulate its oncogenic function have been identified. Prior studies used a proteomic approach to identify a novel interaction between Tcl1 with Ataxia Telangiectasia Mutated. The association of Tcl1 and Ataxia Telangiectasia Mutated leads to activati ...[more]