Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.

ABSTRACT:

Purpose

We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population.

Methods

In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide polymorphisms (SNPs) of four complement pathway genes, including rs800292 and rs1410996 of complement H (CFH), rs9332739 of complement 2 (C2), rs4151667 of complement factor B (CFB), and rs2241394 and rs2230199 of complement 3 (C3). The associations between SNPs and AMD, adjusted by age and sex, were assessed by using logistic regression models and haplotype association analysis.

Results

In our study, two SNPs of CFH and their haplotypes were associated signi

SUBMITTER: Wu L 

PROVIDER: S-EPMC3544419 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature