Ontology highlight
ABSTRACT:
SUBMITTER: Schaap-Oziemlak AM
PROVIDER: S-EPMC3544900 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Schaap-Oziemlak Aneta M AM Schouteden Sarah S Khurana Satish S Verfaillie Catherine M CM
PloS one 20130114 1
Previously we reported that Wnt5a is highly expressed in the murine urogenital ridge-derived UG26-1B6 cells but not embryonic liver-derived EL08-1D2 cells. Mouse long-term repopulating hematopoietic stem cells (LTR-HSC) were maintained in non-contact UG26-1B6 cultures but not EL08-1D2 non-contact cultures, unless Wnt5a was also added to the cultures, suggesting a role for Wnt5a in the in vitro maintenance of LTR-HSC. Here, we investigated if the effect of Wnt5a on adult LTR-HSC activity is HSC-a ...[more]