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Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling.

ABSTRACT: The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.

SUBMITTER: Thoonen R

PROVIDER: S-EPMC3544991 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling.

Thoonen Robrecht R Sips Patrick Y PY Bloch Kenneth D KD Buys Emmanuel S ES

Current hypertension reports 20130201 1

The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide ...[more]

PMID: 23233080

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