Ontology highlight
ABSTRACT:
SUBMITTER: van Veenendaal NR
PROVIDER: S-EPMC3545537 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
van Veenendaal Nicole R NR Ulmer Bärbel B Boskovski Marko T MT Fang Xiefan X Khokha Mustafa K MK Wendler Christopher C CC Blum Martin M Rivkees Scott A SA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121112 2
Antithyroid medications are the preferred therapy for the treatment of Graves' disease during pregnancy. Propylthiouracil (PTU) is favored over methimazole (MMI) due to potential teratogenic concerns with MMI. This study was to determine the teratogenic potential of MMI and PTU using a validated Xenopus tropicalis embryo model. Embryos were exposed to 1 mM PTU (EC(50)=0.88 mM), 1 mM MMI, or vehicle control (water) from stages 2 to 45. Treated embryos were examined for gross morphological defects ...[more]