Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC3546732 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Xu Shunjiang S Zhang Rui R Niu Jingya J Cui Dongsheng D Xie Bing B Zhang Binggui B Lu Kang K Yu Wenjun W Wang Xueyi X Zhang Qingfu Q
International journal of molecular sciences 20121211 12
Oxidative stress plays a critical role in the etiology and pathogenesis of neurodegenerative disorders, and the molecular mechanisms that control the neuron response to ROS have been extensively studied. However, the oxidative stress-effect on miRNA expression in hippocampal neurons has not been investigated, and little is known on the effect of ROS-modulated miRNAs on cell function. In this study, H(2)O(2) was used to stimulate the mouse primary hippocampal neurons to develop an oxidative stres ...[more]