Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading.
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ABSTRACT:
SUBMITTER: Qi Z
PROVIDER: S-EPMC3546734 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading.
Qi Zhengtang Z Zhang Yuan Y Guo Wei W Ji Liu L Ding Shuzhe S
International journal of molecular sciences 20121211 12
We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin- ...[more]
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