TALENs: a widely applicable technology for targeted genome editing.
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ABSTRACT:
SUBMITTER: Joung JK
PROVIDER: S-EPMC3547402 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
TALENs: a widely applicable technology for targeted genome editing.
Joung J Keith JK Sander Jeffry D JD
Nature reviews. Molecular cell biology 20121121 1
Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential the ...[more]
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