Ontology highlight
ABSTRACT:
SUBMITTER: Siesser WB
PROVIDER: S-EPMC3547473 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Siesser William B WB Sachs Benjamin D BD Ramsey Amy J AJ Sotnikova Tatyana D TD Beaulieu Jean-Martin JM Zhang Xiaodong X Caron Marc G MG Gainetdinov Raul R RR
ACS chemical neuroscience 20121001 1
Selective serotonin reuptake inhibitors (SSRIs) are a major class of antidepressants that act by blocking inward transport of serotonin (5-HT) into presynaptic neurons mediated by the serotonin transporter (SERT). Both reuptake and ongoing synthesis are essential in supporting intraneuronal serotonin concentrations in serotonergic neurons. A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and ...[more]