Ontology highlight
ABSTRACT:
SUBMITTER: Asangani IA
PROVIDER: S-EPMC3547524 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Asangani Irfan A IA Ateeq Bushra B Cao Qi Q Dodson Lois L Pandhi Mithil M Kunju Lakshmi P LP Mehra Rohit R Lonigro Robert J RJ Siddiqui Javed J Palanisamy Nallasivam N Wu Yi-Mi YM Cao Xuhong X Kim Jung H JH Zhao Meng M Qin Zhaohui S ZS Iyer Mathew K MK Maher Christopher A CA Kumar-Sinha Chandan C Varambally Sooryanarayana S Chinnaiyan Arul M AM
Molecular cell 20121115 1
Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET, that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27 trimethylation and is associated with gene silencing, was shown to be coordinately expressed and function upstream of MMSET, which mediates H3K36 dimethylation and is associated with active transcrip ...[more]