Ontology highlight
ABSTRACT:
SUBMITTER: Loh ML
PROVIDER: S-EPMC3548168 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Loh Mignon L ML Zhang Jinghui J Harvey Richard C RC Roberts Kathryn K Payne-Turner Debbie D Kang Huining H Wu Gang G Chen Xiang X Becksfort Jared J Edmonson Michael M Buetow Kenneth H KH Carroll William L WL Chen I-Ming IM Wood Brent B Borowitz Michael J MJ Devidas Meenakshi M Gerhard Daniela S DS Bowman Paul P Larsen Eric E Winick Naomi N Raetz Elizabeth E Smith Malcolm M Downing James R JR Willman Cheryl L CL Mullighan Charles G CG Hunger Stephen P SP
Blood 20121204 3
One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IKZF1, and poor outcome. Prior studies demonstrated that approximately half of these patients had genomic lesions leading to CRLF2 overexpression, with half of such cases harboring somatic mutations in ...[more]