Dataset Information

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

ABSTRACT:

Background

Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents.

Objectives

We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother-child study.

Methods

Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires.

Results

Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight.

Conclusions

Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.

SUBMITTER: Pedersen M

PROVIDER: S-EPMC3548277 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Publications

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

Pedersen Marie M von Stedingk Hans H Botsivali Maria M Agramunt Silvia S Alexander Jan J Brunborg Gunnar G Chatzi Leda L Fleming Sarah S Fthenou Eleni E Granum Berit B Gutzkow Kristine B KB Hardie Laura J LJ Knudsen Lisbeth E LE Kyrtopoulos Soterios A SA Mendez Michelle A MA Merlo Domenico F DF Nielsen Jeanette K JK Rydberg Per P Segerbäck Dan D Sunyer Jordi J Wright John J Törnqvist Margareta M Kleinjans Jos C JC Kogevinas Manolis M

Environmental health perspectives 20120923 12

<h4>Background</h4>Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents.<h4>Objectives</h4>We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother-child study.<h4>Methods</h4>Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the ...[more]

PMID: 23092936

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Dataset Information

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

Background

Objectives

Methods

Results

Conclusions

Publications

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

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