Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review.
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ABSTRACT:
SUBMITTER: Lahti L
PROVIDER: S-EPMC3548603 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review.
Lahti Leo L Schäfer Martin M Klein Hans-Ulrich HU Bicciato Silvio S Dugas Martin M
Briefings in bioinformatics 20120322 1
A variety of genome-wide profiling techniques are available to investigate complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher level interactions that cannot be detected based on individual observations. A standard integration task in cancer studies is to identify altered genomic regions that induce changes in the expression of the associated genes based on joint analysis of genome-wide gene expression and copy number profi ...[more]
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