Ontology highlight
ABSTRACT:
SUBMITTER: Zimmermann B
PROVIDER: S-EPMC3548605 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Zimmermann Bernhard B Hill Matthew M Gemelos George G Demko Zachary Z Banjevic Milena M Baner Johan J Ryan Allison A Sigurjonsson Styrmir S Chopra Nikhil N Dodd Michael M Levy Brynn B Rabinowitz Matthew M
Prenatal diagnosis 20121030 13
<h4>Objective</h4>This study aims to develop a noninvasive prenatal test on the basis of the analysis of cell-free DNA in maternal blood to detect fetal aneuploidy at chromosomes 13, 18, 21, X, and Y.<h4>Methods</h4>A total of 166 samples from pregnant women, including 11 trisomy 21, three trisomy 18, two trisomy 13, two 45,X, and two 47,XXY samples, were analyzed using an informatics-based method. Cell-free DNA from maternal blood was isolated, amplified using a multiplex polymerase chain react ...[more]