Ontology highlight
ABSTRACT:
SUBMITTER: Goetz MP
PROVIDER: S-EPMC3548984 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Goetz Matthew P MP Suman Vera J VJ Hoskin Tanya L TL Gnant Michael M Filipits Martin M Safgren Stephanie L SL Kuffel Mary M Jakesz Raimund R Rudas Margaretha M Greil Richard R Dietze Otto O Lang Alois A Offner Felix F Reynolds Carol A CA Weinshilboum Richard M RM Ames Matthew M MM Ingle James N JN
Clinical cancer research : an official journal of the American Association for Cancer Research 20121204 2
<h4>Purpose</h4>Controversy exists about CYP2D6 genotype and tamoxifen efficacy.<h4>Experimental design</h4>A matched case-control study was conducted using the Austrian Breast and Colorectal Cancer Study Group Trial 8 (ABCSG8) that randomized postmenopausal women with estrogen receptor (ER)-positive breast cancer to tamoxifen for 5 years (arm A) or tamoxifen for 2 years followed by anastrozole for 3 years (arm B). Cases had disease recurrence, contralateral breast cancer, second non-breast canc ...[more]